IL-13, TLR8, VCAM1, IDO1, IL-4, IL-17A, CD28, CCR7, CXCR4 and TLR9 were the 10 hub genes ultimately screened from the PPI network (Figure 2B); These genes may serve as the target genes for the pathogenesis of keloids, which need further verification. This evidence concerns the gene CD28 and keloid.