According to Reeves and Friedman, fibronectin synthetized in endothelial cells plays a key role in the activation of hepatic stellate cells in chronic liver injury by toxins, disorders of the immune system, and in viral and parasitic infections, as well as in some other rare liver diseases caused by genetic disorders such as galactosemia and Wilson’s disease [33]. This evidence concerns the gene FN1 and digestive system neoplasm.