CREB1 and Cognitive impairment: To further investigate the mechanism of action involved in the therapeutic effect of NX210c on cognitive deficits, the cortex and hippocampus of these mice were collected right after the T-maze to measure the protein levels of GluN2A-NMDAR and phosphorylated CREB (pCREB), a downstream mediator of NMDAR signaling implicated in learning and memory [28] (Figure 3B,C).