Some studies have reported upregulation of TREM-2 in active RA synovium [43] and overexpression of TREM-2 in the synovial tissue of rats with CIA [44], suggesting blockade of TREM-2 signaling or depletion of TREM-2-expressing myeloid cells from synovium as potential anti-arthritic approaches. The gene discussed is TREM2; the disease is rheumatoid arthritis.