Lastly, it was recently shown that hypoxia simultaneously upregulates HIF-1α and transient receptor potential melastatin subfamily member 7 (TRPM7) in androgen-independent PC cells and that knockdown of TRPM7 inhibited hypoxia-induced migration and invasion via the increased RACK1-mediated degradation of HIF-1α [49]. Here, HIF1A is linked to pachyonychia congenita.