PC patients who develop resistance to bicalutamide are oftentimes responsive to the next-generation antagonist enzalutamide, which (a) has an eightfold higher affinity for AR than bicalutamide and (b) is a robust inhibitor of AR signaling that blocks AR nuclear translocation and coactivator interactions and attenuates the DNA binding capacity of AR [31]. Here, AR is linked to pachyonychia congenita.