Notably, this study found that 20% of AR transcripts had a 3 kb deletion within the normally 6.7 kb long 3′ UTR and that this shorter AR UTR splice variant, which was also detectable in patients’ post-treatment tumor samples and PC patient sera, had a significantly increased stability/half-life, which potentially conferred a survival advantage to the tumor cells. Here, AR is linked to pachyonychia congenita.