Maes et al. [44] combined HAMD and HAMA scores, as well as the four WHO-QoL domains and Sheehan disability scores, in MDD/BD patients to create one latent construct that was highly predicted by OSTOX neurotoxicity and decreased antioxidant activity of the HDL-paraoxonase 1 complex [44]. Here, PON1 is linked to major depressive disorder.