In line with these findings, we have previously demonstrated an interesting role of Nerve Growth Factor (NGF) and its receptors Tropomyosin-related kinase A (TrKA) and neurotrophin receptor p75 (p75NTR) in the most typical smoke-induced disease: Chronic Obstructive Pulmonary Disease (COPD) [14]. This evidence concerns the gene NTRK1 and chronic obstructive pulmonary disease.