Several mechanisms have been proposed to explain the involvement of periodontal disease and its ability to potentiate the severity of COVID-19 [16], including the aspiration of periodontal pathogenic microbiota, which represents a powerful proinflammatory stimulus or by inducing ACE2 overexpression, with a subsequent increase in IL-6 and IL-8 cytokines by bronchial cells and alveolar epithelial cells [17]. Here, CXCL8 is linked to periodontal disorder.