About the genetic polymorphisms and the clinicopathologic characteristics of lung adenocarcinoma, the GAS5 SNP rs145204276 Ins/Del + Del/Del demonstrated a higher distribution in advanced tumor stage (p = 0.030), larger tumor T status (p = 0.019), positive lymph node status (p = 0.014) and the presence of distal metastasis (p = 0.011) when compared to the GAS5 rs145204276 wild type in the EGFR wild type group (Table 3). The gene discussed is GAS5; the disease is neoplasm.