Concerning the genetic polymorphism of GAS5 and the clinical characters of lung adenocarcinoma with different EGFR genotypes, the lung adenocarcinoma patients with EGFR wild type and GAS5 SNP rs145204276 Ins/Del + Del/Del would experience higher tumor stage, larger tumor T status, advanced lymph node invasion and distal metastasis compared to those patients without the GAS5 variant. Here, EGFR is linked to lung adenocarcinoma.