The present study analyzes, in an integrative way, the complexity of the effects induced by the COVID-19 pandemic aiming at a series of relevant parameters, such as thyroid dysfunction correlated symptoms related to the measures to reduce the spread of COVID-19, a large number of investigated subjects, family history of endocrine diseases, life and work style, personal medical history, treatment, clinical general examination (including weight and height), blood tests (complete blood count, TSH, FT4, Thyroid peroxidase antibodies—TPO, serum Calcium), thyroid ultrasound. This evidence concerns the gene TPO and endocrine system disorder.