Interestingly, our results revealed that the CERS3 is significantly associated with Cer-16 (Table 3), suggesting that the two SNPs (rs72759132 and rs4246316) at CERS3 locus of individuals with MetS may play a role in increasing the plasma concentration of long chain ceramides such as Cer-16 rather than very long chain ceramides such as Cer-26. Here, CERS3 is linked to metabolic syndrome.