HPSE2 and neoplasm: For example, a study in California sea lions demonstrated that urogenital carcinoma was significantly associated with homozygosity of a microsatellite locus within an intron of the heparanase 2 gene HPSE2 [16], and facial tumor disease regression is associated with RAS11A activation in Tasmanian devils [18], both of which are implicated in several human carcinomas.