Univariate analysis of prognostic factors for overall survival in patients with HCC demonstrated high hsa_circ_0003570 expression (hazard ratio [HR], 0.515; 95% CI, 0.331–0.801; p = 0.003); multiple tumors (HR, 2.408; 95% CI, 1.549–3.743; p < 0.001); AFP level > 200 ng/mL (HR, 2.938; 95% CI, 1.885–4.579; p < 0.001); poor CTP class (HR, 3.259; 95% CI, 1.881–5.648; p < 0.001); chronic hepatitis B (HR, 0.594; 95% CI, 0.383–0.922; p = 0.020); and curative treatment (HR, 0.141; 95% CI, 0.086–0.231; p < 0.001). The gene discussed is AFP; the disease is hepatocellular carcinoma.