In addition to Tangier disease, variations and changes in the ABCA1 gene increase the risk of atherosclerosis [111,112], familial hypercholesterolemia [113], coronary heart disease [114], including myocardial infarction [115,116] and ischemic stroke [112,117], and can be considered as a prognostic biomarker [118,119]. This evidence concerns the gene ABCA1 and Tangier disease.