EGR1 and disease of the tendon: It is also worth mentioning that miR-148a-3p promotes thrombospondin-4 expression and enhances angiogenesis during tendinopathy; miR-124 suppresses collagen formation of the human tendon [155], and miRNA124-3p directly binds and suppresses the expression of early growth response-1 (EGR1) and suppresses the synthesis of collagen during tenogenic differentiation (the transcription factor EGR1 promotes tendon repair and regulates tendon differentiation) [149].