In a meta-analysis, Shi et al. analyzed 16 IRS-1 Gly972 polymorphism and PCOS case control studies including 1851 PCOS cases and 2017 controls and concluded that there was a significant association (p = 0.004, OR = 0.57, 95% CI: 0.39–0.84) of the polymorphism with PCOS [21]. The gene discussed is IRS1; the disease is polycystic ovary syndrome.