The up-regulated pathways mainly involved cytokine receptor signaling pathway, IL17 signaling pathway, TNF signaling pathway, extracellular matrix, and other related pathways, stem cells pluripotency and other signaling pathways (Figure 3A), down-regulated pathways mainly involve cell adhesion molecules, calcium signaling pathways, and rheumatoid arthritis (Figure 3B). Here, TNF is linked to rheumatoid arthritis.