Simultaneously, high SERPINE2 expression was an independent poor prognostic factor in oral squamous cell carcinoma (OSCC), lung adenocarcinoma, urothelial carcinoma and endometrial cancer [31,32,33,34], and SERPINE2 was identified as a promising therapeutic target in melanoma metastasis and in the radio-resistance of lung cancer. This evidence concerns the gene SERPINE2 and melanoma.