LHX2 and esophageal squamous cell carcinoma: To determine the role of LHX2 in ESCC, firstly, we analyzed the available TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) ESCC datasets, and we found that the mRNA levels of LHX2 were remarkably upregulated in ESCC tissues compared with the levels in normal tissues or matched adjacent normal tissues (Figure 1B,C).