TMPyP4 (25 μM) and 317605 (1 μM) were examined in a luciferase system that contained either no promoter (EV) or the full length KRAS promoter (KRAS/FL [38]), as well as in pancreatic cancer cell lines that harbored mutant KRASG12D proteins—Panc1 and AsPc1 (Figure 1C). This evidence concerns the gene KRAS and familial pancreatic carcinoma.