Changes in transcription tied to cytotoxicity were also examined in Panc1 pancreatic cancer cells, wherein trends indicating a decrease in KRAS with compounds NSC and 9a were also observed (vehicle normalized expression was noted to be 0.57 ± 0.36 and 0.55 ± 0.34), but significance was not noted. This evidence concerns the gene KRAS and familial pancreatic carcinoma.