Additionally, eight genes (CACNA1C, CACNA1E, EYA2, FARP1, RBFOX1, SOX5, TCF4, and TENM2) residing in MDD-associated loci were identified as differentially methylated in four different study designs, and nine genes (ADARB2, AMN, ESRRG, KIRREL3, MAD1L1, MAML3, MEGF11, SORCS3, and SYNE2) in three different study designs (Table 1, Figure 2). Here, TCF4 is linked to major depressive disorder.