Additionally, eight genes (CACNA1C, CACNA1E, EYA2, FARP1, RBFOX1, SOX5, TCF4, and TENM2) residing in MDD-associated loci were identified as differentially methylated in four different study designs, and nine genes (ADARB2, AMN, ESRRG, KIRREL3, MAD1L1, MAML3, MEGF11, SORCS3, and SYNE2) in three different study designs (Table 1, Figure 2). The gene discussed is CACNA1C; the disease is major depressive disorder.