Additionally, eight genes (CACNA1C, CACNA1E, EYA2, FARP1, RBFOX1, SOX5, TCF4, and TENM2) residing in MDD-associated loci were identified as differentially methylated in four different study designs, and nine genes (ADARB2, AMN, ESRRG, KIRREL3, MAD1L1, MAML3, MEGF11, SORCS3, and SYNE2) in three different study designs (Table 1, Figure 2). This evidence concerns the gene SOX5 and major depressive disorder.