EuroFlow consortium have proposed an optimized diagnostic panel for BCP-ALL that consists of maturation stage markers: CD34, CD20, CD10, CD38, Terminal deoxynucleotidyl transferase (TdT) and IgM (heavy M/μ immunoglobulin chain); leukemia associated immunophenotype (LAIP) markers: CD33, CD13, CD9, CD81, and markers useful for possible genetic subtype indication: CD15, CD66c, CD123, NG2 [10,11]. This evidence concerns the gene CD40LG and acute lymphoblastic leukemia.