Segmental duplications (SDs), which are considered a common phenomenon and account for approximately 7% (or 218 Mbp) of the human genome [47], have been reported to be associated with the formation of chimeric fusion genes, such as BCR::ABL1 through t(9;22)(q34;q11.2) [48] and RUNX1::USP42 through ins(21;7)(q22;p15p22) [49], in myeloid malignancies. Here, RUNX1 is linked to myeloid neoplasm.