The clinicopathologic and cytogenetic features of all these cases with rare CBFB rearrangement, including our patient with t(2;16)/CBFB::PPP1R7, mimicked that of classic inv(16)/t(16;16) AML with CBFB::MYH11 (Figure 1), except the AML case with t(1;16)(q43;q22)/CBFB rearrangement reported by Gupta et al. [18], which initially presented as a deceptive acute promyelocytic leukemia (APL) with multiple Auer rods in the abnormal promyelocytes, which has been finally diagnosed and treated as CBF AML. The gene discussed is CBFB; the disease is acute promyelocytic leukemia.