CBFB and acute myeloid leukemia: As reported previously by others and our group (Table 1), some AML cases were highly suspicious for a CBFB rearrangement, with novel partner gene(s), other than MYH11, especially those with t(1;16)(q21;q22), t(2;16), t(3;16), t(5;16), and t(16;19) with 16q22 involvement by conventional cytogenetic analyses; in some of these cases, CBFB FISH clearly demonstrated that the 3′CBFB signals were translocated to the partner chromosomes.