In addition to AML, CBFB rearrangements have been reported in patients with other types of malignant neoplasms involving the brain [28,29,30], breast [29], lung [29,30], oral cavity, gastrointestinal tract [29,30,31], skin [29], and ovary and uterus [29,30]. Here, CBFB is linked to acute myeloid leukemia.