BRCA2 and breast cancer: Large cohort studies estimate a cumulative BC risk to age 80 years of 72% for BRCA1 and 69% for BRCA2 pV carriers, for contralateral BC of 20–25% for BRCA1 and 7–13% for BRCA2 pV carriers 10 years after first BC [1], and 40% for BRCA1 and 26% for BRCA2 pV carriers 20 years after first BC [2].