In addition, an Algerian recent study have screened MLH1, MSH2 and MSH6 genes among 21 families from East of Algeria and have identified the MSH2 (c.728G>A) mutation in two cases (44 and 38 years old) with CCR belonging to the same family with colon cancer family history [62]. The gene discussed is MSH6; the disease is colonic neoplasm.