In our study, we chose 13 SNPs in the NF-κB1 gene, NF-κB2 gene, RELA gene, RELB gene and REL gene of the NF-κB pathway to investigate the association between the NF-κB pathway variations and bone response to zoledronic acid therapy in Chinese postmenopausal women with osteoporosis or osteopenia. This evidence concerns the gene NFKB1 and osteoporosis.