Additional markers relevant to the pathogenesis (with the immune microenvironment) of celiac disease were also found within the core enrichment, including LAG3, MICB, RUNX3, CASP3, IL15RA, FASLG, CTLA4, IL10RA, GZMA, RGS1, IRF4, XBP1, CD69, NFKB1, BTLA, TIGIT, ICOS, CD86, ITGAX, CD274, TNFAIP3, MMP3, MIF, BTK, and MYD88. This evidence concerns the gene XBP1 and celiac disease.