Additional markers relevant to the pathogenesis (with the immune microenvironment) of celiac disease were also found within the core enrichment, including LAG3, MICB, RUNX3, CASP3, IL15RA, FASLG, CTLA4, IL10RA, GZMA, RGS1, IRF4, XBP1, CD69, NFKB1, BTLA, TIGIT, ICOS, CD86, ITGAX, CD274, TNFAIP3, MMP3, MIF, BTK, and MYD88. The gene discussed is IRF4; the disease is celiac disease.