In univariable analyses, the risk of CKD diagnosis was associated with older age at baseline, history of type 2 diabetes, hypertension, tubule-interstitial nephritis, gout and urolithiasis at baseline, and time-updated absolute CD4 cell count <200 cells/mm3 (all p ≤ 0.05, Table 3). The gene discussed is CD4; the disease is chronic kidney disease.