IRF5 and inflammatory bowel disease: For example, polymorphisms of FCGR3A are associated with susceptibility to ulcerative colitis [32]; gene expression genotype analysis identified GSDMB as a contributor to inflammatory bowel disease susceptibility [33]; distinct IFNG methylation status was found in a subset of ulcerative colitis patients based on reactivity to microbial antigens [34], reducing IRF5 expression attenuated colitis in mice but impairing the clearance of intestinal pathogens [35]; and in children, MMP3 was correlated with several clinical and endoscopic activity on ulcerative colitis in children [36].