DNAM-1 is found in CD8+ T cells, cytokine induced killer (CIK) cells, and NK cells, [15] where it induces the release of cytokines, such as interferon (IFN)-γ, and stimulates their cytotoxic activity that ultimately lead to the apoptosis of tumor targets or infected cells [15,16]. The gene discussed is CD226; the disease is neoplasm.