IDH1 and glioblastoma: Figure 6 shows the chemical reaction and metabolic pathways present in a brain tumor cell, with emphasis on enzymatic effectors—IDH1 and IDH2 mutations. IDH1 gene mutation is found in 5% of patients having a primary glioblastoma; however, 70% to 80% of patients develop a glioma of grade II to III and secondary glioblastoma [90].