ERBB2 and breast cancer: Of note, Δ16ECTM phages induced a lower anti-HER2 antibody response in comparison with ECTM-phages, but the Δ16ECTM-phage-induced antibodies can contribute to protection by mediating ADCC, as demonstrated ex vivo using the CAM6 cell line (Figure 3F), which can be considered the in vitro counterpart of Δ16HER2 mammary tumors [29].