For chronic myelogenous leukemia (CML), it has been reported that the TRAF2-interacting TNFRSF receptor CD27 stimulates the oncogenic Wnt-β-catenin-TNIK-TCF4 pathway, resulting in enhanced proliferation of leukemia stem cells and leukemia progression in a TRAF2-dependent manner [236]. This evidence concerns the gene TCF4 and leukemia.