Peng at al [92] could indicate that TRAF2 contributes to EGF-induced ribosomal S6 kinase 2 (RSK2) activation in colon cancer cell lines and Jia et al. [72] reported recently that TRAF2 binds LRPPRC to ubiquitinate argininosuccinate synthase 1 marking this enzyme for degradation resulting in reduced arginine synthesis and the latter is required for tumor growth. This evidence concerns the gene RPS6KA3 and neoplasm.