To further elucidate the correlation of MMP27, TNFRSF11B and TNFSF11 mRNA expression levels with tumor invasiveness (T4a) in silico, patients with low MMP27, TNFRSF11B and TNFSF11 expression (M1), as well as patients with high gene expression (M2), were selected. This evidence concerns the gene TNFRSF11B and neoplasm.