Afterwards, an analysis of the expression of MMP-27, RANKL and OPG at the bone-tumor interface was performed by immunohistochemistry (IHC) using tissue microarrays (TMAs) from oral cancer patients who had undergone either partial or segmental resection of the mandible at the University Hospital of Regensburg. Here, TNFRSF11B is linked to lip and oral cavity carcinoma.