To further elucidate the correlation of MMP27, TNFRSF11B and TNFSF11 mRNA expression levels with tumor invasiveness (T4a) in silico, patients with low MMP27, TNFRSF11B and TNFSF11 expression (M1), as well as patients with high gene expression (M2), were selected. The gene discussed is TNFSF11; the disease is neoplasm.