First, 18 of 21 m6A regulators (METTL3, METTL14, RBM15B, KIAA1429, CBLL1, ZC3H13, ALKBH5, FTO, YTHDC1, YTHDC2, YTHDF1, YTHDF2, IGF2BP1, HNRNPA2B1, HNRNPC, FMR1, LRPPRC, ELAVL1) were identified as differentially expressed in PCa compared to normal prostate tissue (Supplementary Figure S3B), suggesting that most m6A regulators were biologically pro-active in PCa. Here, LRPPRC is linked to posterior cortical atrophy.