In the context of GBM, considering the presence of immune cells with immunosuppressive action, an immune checkpoint has recently been identified, represented by BACE1; although BACE1 is a beta-secretase involved in the cleavage of the amyloid precursor protein [48] and used in the treatment of Alzheimer’s disease (AD), its inhibition was effective for GBM. The gene discussed is APP; the disease is Alzheimer disease.