However, subsequent studies have found that the interaction of adenosine with A2AAR induces inhibition of the adaptive immune response, inhibiting the function of CD4+ and CD8+ T cells and NKCs and IL-2/Nkp46-activated NK cells specifically via A2AAR [110], thus promoting tumor escape from the immune system and metastasis [111,112]. This evidence concerns the gene CD4 and neoplasm.