IL10 and neoplasm: STAT3 (signal transducers and activators of transcription 3) promotes the immunosuppressive tumor microenvironment through multiple mechanisms, including increased secretion of IL-10 and IL-23 (interleukin-10 and interlekin-23), MDSCs (myeloid-derived suppressor cells), and M2 tumor-associated macrophages, as well as inhibiting the development of dendritic cells.