In total, 49 of 70 melanomas (70%) harbored a TERT promoter mutation, including 1,295,228 C>T (n = 18), 1,295,250 C>T (n = 25), 1,295,242-43 CC>TT (n = 5), and 1,295,161 A>C (n = 1). The gene discussed is TERT; the disease is melanoma.