PTEN and neoplasm: In addition, MIR-103a and MIR-301a-3p target the expression of phosphatase and tensin homolog (PTEN), subsequently activating STAT3, RAC-alpha serine/threonine protein kinase (AKT), and PI3Kγ, thereby also skewing macrophages to the tumor-promoting M2 phenotype [45,46].