In addition, increased levels of MIR-29a and MIR-92a within the hypoxic glioma-derived EVs decrease the expression of the high-mobility group box transcription factor 1 (Hbp1) and protein kinase CAMP-dependent type I regulatory subunit alpha (Prkar1α) genes in MDSCs, respectively [74]. The gene discussed is HBP1; the disease is central nervous system cancer.