IGFBP3 and cancer: In addition, various other factors known to modulate MDSC function are increased in EVs derived from hypoxic cancer cells, including MIR-210, MIR-494, C-C motif chemokine ligand (CCL)2, and insulin-like growth-factor-binding protein 3 (IGFBP-3) (Table 3) [75,76,77].