The growth curve of the tumors in each group of the mice was assessed: VHH1-28BBz CDH17 CAR-T cells induced tumor mass reduction until complete eradication of all tumors after 42 days; VHH1-BBZ showed progressive volume reduction but were not able to cause tumor elimination; conversely, CDH17-UTD therapy failed to control tumor growth. Here, CDH17 is linked to neoplasm.