Öhlund et al. focused on the fact that CAFs located in the proximity of tumor cells express high levels of α-SMA, while CAFs distal to the tumor cells express low levels of α-SMA and instead express high levels of IL6 and demonstrated that α-SMA-high (myofibroblastic CAFs; myCAFs) and αSMA-low/IL6-high (inflammatory CAFs; iCAFs) subpopulations were each located in spatially distinct regions in the same PDAC tissue [37]. The gene discussed is ACTA1; the disease is neoplasm.