To investigate the significance of BRD3OS (LINC00094) in epidermal carcinogenesis, expression was studied in the HaCaT cell line, which is derived from human epidermal keratinocytes and lacks functional p53, as well as in three HaCaT-derived Ha-ras–transformed cell lines (A5, II-4, and RT3), which are representative in vitro models for progressive stages of cSCC tumors. This evidence concerns the gene BRD3OS and skin squamous cell carcinoma.