Besides its major role in T-ALL, miR-146a seems to be implicated in B-cell maturation through miR-the 146a/NFKB1/BCL11A pathway and in megakaryopoiesis regulated by the ZBTB16/miR-146a/CXCR4 axis (ZBTB16 or zinc finger and BTB domain-containing 16 protein alias PLZF of ZNF145; C-X-C motif chemokine receptor 4 alias CD184 or fusin) [185,186]. The gene discussed is ZBTB16; the disease is acute lymphoblastic leukemia.