In summary, our systematic review and meta-analysis showed that SNPs in pri-miR-34b/c and miR-100 genes have been linked with protection again childhood ALL, whereas SNPs rs3805500 in DROSHA, rs3746444 in miR-449b, rs2505901 in miR-938, rs12402181in miR-3117 and rs62571442 in miR-3689d-2 genes have been associated with susceptibility to B-ALL (Table 2). Here, DROSHA is linked to acute lymphoblastic leukemia.