Downregulation of miR-16 has been long known to be a main event in CLL (chronic lymphocytic leukemia), but its upregulation seems to play a pivotal role in regulating BCL2 (by binding the 3′-UTR region of BCL2) and in mediating prednisolone-induced apoptosis in childhood T-ALL [79,187,188,189,190]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.