Other roles of miR-210 include (i) immune response: negative feedback regulator in lipopolysaccharide/toll-like receptor 4 (LPS/TLR4) signaling; (ii) transformation, leukemogenesis and chemotactic invasion: positive feedback loop with NF-κB, IL-6 and STAT3; (ii) DNA repair of double-stranded breaks in cases of hypoxia-induced genomic instability by targeting RAD52; and (iv) activation of the PI3K/AKT pathway by targeting SHIP1 (also known as INPP5 inositol polyphosphate-5-phosphatase D) has been correlated with MDS (myelodysplastic syndrome) development [172]. This evidence concerns the gene IL6 and myelodysplastic syndrome.