Furthermore, miR-155 seems to promote ALL cell proliferation by targeting ZBTB18 (also known as ZNF238; encoding zinc finger and BTB domain-containing 18 protein), whereas anti-miR-155 treatment seems to prevent CD154-mediated repression (i.e., CD40 ligand) of BCL2 and to reduce proliferation in leukemic cells in vitro [27,110]. Here, CD40LG is linked to acute lymphoblastic leukemia.