A mouse model demonstrated that loss of miR-145 results in leukemia, whereas another study has positively correlated miR-145 levels with the expression of proapoptotic genes PRKAA1, PTEN, FOXO3 (encoding Forkhead Box O3 protein), BCL2L11 (aka BIM), DIDO1 (encoding death inducer-obliterator 1) and BCL2L13 [158,181]. The gene discussed is PTEN; the disease is leukemia.