Upregulation of miR-125b in childhood ALL is associated with the methylation of the promoter regions of tumor suppressor genes PPP1CA (encoding protein phosphatase 1 catalytic subunit alpha), BTG2 (gene of B-Cell translocation gene anti-proliferation factor 2) and PTEN (encoding phosphatase and tensin homolog) and their downregulation (reversed by DNA methyltransferase inhibitor decitabine) [108]. Here, PTEN is linked to acute lymphoblastic leukemia.