Conversely, upregulation of miR-196b is prominent in pediatric KMT2A-r cases [29,83,100,116] and in some T-ALL subgroups (such as HOXA-r, PICALM-MLLT10 or CALM-AF10, inv(7)(p15q35) and SET-NUP214 cases), especially when aberrant expression of HOXA genes is evident [20,83,116]. The gene discussed is PICALM; the disease is acute lymphoblastic leukemia.