AKT1 and acute lymphoblastic leukemia: On the contrary, GC resistance in T-ALL might be explained by the upregulation of glycolysis, oxidative phosphorylation, cholesterol synthesis, glutamic acid synthesis, fast growth rate and activation of PI3K/AKT/mTOR (phosphoinositide 3-kinases, AKT serine/threonine kinases and mTOR pathway) and the MYC-signaling pathways.