Interestingly, miR-19 targets BIM (BCL2-like 11 protein) encoded by BCL2L11, PRKAA1 (encoding protein kinase AMP-activated catalytic subunit alpha 1), PTEN (encoding phosphatase and tensin homolog) and PPP2R5E (encoding protein phosphatase 2 regulatory subunit B’epsilon), whereas miR-92 regulates FBX7 (encoding F-box protein 7), BCL2L11, IKZF1 (encoding IKAROS family zinc finger 1 protein), PTEN and NF1 (encoding Neurofibromin 1), indicating that regulators of PI3Ks are crucial for childhood T-ALL [79,193]. The gene discussed is PTEN; the disease is acute lymphoblastic leukemia.