These oncomirs lead to leukemogenesis by affecting several pathways, mainly by inhibiting TERT (telomerase reverse transcriptase) mRNA, PHF6 (PHD finger protein 6, especially in NOTCH1-driven T-ALL models), BMI1 proto-oncogene and UBE2W (encoding ubiquitin-conjugating enzyme E2 W), an ubiquitin ligase involved in the BRCA DNA repair associated-pathway [46,149,151,152]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.