Point mutations, which represent the predominant mechanism by which p53 protein loses its normal tumor suppressor function, are located within the DNA binding domain of the protein, and 30% of them fall within what is called six “hotspot” residues, namely amino-acid residues R175H, G245S, R248Q, R249S, R273H and R282W, in various cancers. Here, TP53 is linked to cancer.