However, eight mutations account for one-third of all TP53 mutations found in tumors, suggesting some homogeneity due to these mutations preferentially occurring because of environmental factors, or being the most impactful in a range of tissue types, occurring by virtue of the features of the sequences in these regions, i.e., CpG sites or because they are GOF-tumor-promoting mutations (recently reviewed in [36]). Here, TP53 is linked to neoplasm.