By summarizing recent results, we identify ten neurotransmitters as key players in GBM behaviors, which could be classified according to their chemical constitution: (1) acetylcholine (Ach); (2) amino acids, such as glutamate (Glu) and gamma-aminobutyric acid (GABA); (3) biogenic amines, such as dopamine, serotonin (5-HT) and norepinephrine (NE); (4) neuropeptides, such as substance P (SP) and neuropeptide Y (NPY); (5) purines, such as adenosine triphosphate (ATP); (6) gases, such as nitric oxide (NO) [14]. Here, NPY is linked to glioblastoma.