(i)lead to the caspase-dependent cell apoptosis and an accumulation of cells in phase G0/G1 in a dose-dependent fashion, thus, resulting in the reduction of cell activity and the promotion of LDH release, (ii)attenuate cell invasion and migration, (iii)induce the death of GBM cells through suppressing mGluR1/PI3K/AKT/mTOR signaling. This evidence concerns the gene PIK3CA and glioblastoma.