(i)significant cell growth inhibition,(ii)suppress Ca2+ permeability and induce high levels of cell apoptosis, (iii)upregulate GluR expression in U87 and U138 cell line(i)Glucose uptake attenuation in all glioblastoma cells,(ii)have no induction on cell apoptosis,(iii)reduce exorbitant extracellular glutamate levels. The gene discussed is GSR; the disease is glioblastoma.