Univariate Cox regression analysis showed that the 10-GPS and the stage were significantly associated with the prognosis of early HCC, and multivariate Cox regression analysis confirmed that the 10-GPS remained an independent predictor after adjusting for clinical variables, including stage, histologic grade, vascular invasion, AFP, and Child–Pugh grade of cirrhosis (Figure 1G). Here, AFP is linked to hepatocellular carcinoma.