CTLA4 and neoplasm: Interestingly, while MSS/CD8+ CRCs were characterized by an upregulation of seven immune signatures (TIS, IFN gamma signaling, MHC2, CD45, CTLA4, and PD-L2) and the overexpression of tumor-intrinsic responses such as APM and the signature measuring key components of the immunoproteasome, MSI/CD8− tumors did not show any of them.