Interestingly, MSS/CD8+ CRCs were characterized by an upregulation of seven immune signatures (TIS, IFN gamma signaling, MHC2, CD45, CTLA4, and PD-L2) and overexpression of tumor-intrinsic responses such as APM and the signature measuring key components of the immunoproteasome. Here, CTLA4 is linked to neoplasm.