Interestingly, 26 out of 39 CD8+ BRAF-CRCs (66.7%) were enlisted in cluster 1, while 12 CD8+ cases belonged to the intermediate cluster 2 (30.7%) and only 1 CD8+ CRC were found among cluster 3 (cold, 2.6%) cases. This evidence concerns the gene BRAF and colorectal carcinoma.