Various systemic therapies have been developed for unresectable HCC, including the multikinase inhibitors sorafenib [1], regorafenib [5], cabozantinib [6], and lenvatinib [2], an antibody against VEGFR2, ramucirumab [7], and the combination of the programmed death ligand 1 (PD-L1) inhibitor atezolizumab and the VEGF inhibitor bevacizumab. Here, VEGFA is linked to hepatocellular carcinoma.