Cu2+ was reduced to Cu+ with the help of sodium ascorbate, triggering the copper–catalyzed azide–alkyne cycloaddition reaction, which produced resveratrol derivatives to kill cancer cells, and Zn2+ was involved in the DNAzyme cleavage of human early growth response–1 (EGR–1) mRNA as a cofactor, inhibiting the proliferation and migration of cancer cells [89]. The gene discussed is EGR1; the disease is cancer.