RNASE1 and cancer: For individual GT, Jia et al. encapsulated RNase A in ZIF–8 with an average size of 425.3 nm [91], and confocal laser scanning microscopy (CLSM) images showed that ZIF–8 effectively helped RNase A uptake by cells, and 3–(4,5–dimethylthiazol–2–yl)–2,5–diphenyltetrazolium bromide (MTT) assay confirmed that RNase A@ZIF–8 maximally inhibited tumor cell proliferation compared with single ZIF–8 and RNase A. In addition, Alyami et al. reported a nanoplatform C3–ZIF, and they used ZIF–8 as a vector to deliver the CRISPR/Cas9 gene editing elements and coated cancer cell membranes on the surface.