Mac-2binding protein (Mac-2BP) plays a role in cell–cell and cell–matrix adhesion by binding to Galectin-1, Galectin-3, fibronectin and collagen [92], which is a candidate biomarker in nonalcoholic fatty liver disease diagnosis and prostate cancer diagnosis [93,94]. The gene discussed is LGALS3; the disease is metabolic dysfunction-associated steatotic liver disease.