SPRY2 and cancer: Finally, by considering the genes recapitulating IL-3 biological functions, we proposed a model, including IL-3Rα, SNAI1, ZEB1, VIM, CTNNB1, MMP2, SPRY2, and CD274, that remarkably discriminates cancer aggressiveness (AUC = 0.86 95% CI = 0.82–0.89) (Figure 8C).