CD274 and neoplasm: Moreover, it has been shown that, in response to IL-3, tumour-derived endothelial cells (TECs) release extracellular vesicles (EVs) able to promote vessel growth [25], epithelial-to-mesenchymal transition (EMT), TNBC metastatic spread [22], and tumour immune evasion by upregulating the programmed cell death-ligand 1 (PD-L1) in myeloid cells [26].